Best Enterprise AI Chatbots for Healthcare for Better Patient Engagement

There’s a notion that healthcare systems are struggling with patient engagement because they lack data. The truth is that they’re just struggling to act fast enough. What they’re missing is the right enterprise AI chatbot to make all the difference.

In the healthcare sector, where scale, security, and real-time response matter just as much as empathy, these smart platforms are stepping in to streamline communication, reduce manual workloads, and close the gaps that frustrate both patients and providers. Here’s a look at the patient engagement solutions doing it best.

1. TeleVox

TeleVox operates as the industry-leading provider of omnichannel patient relationship management platforms, specializing in conversational AI solutions designed specifically for healthcare.

Their HIPAA-compliant virtual agent, SMART Agent, takes queries by phone, text, and online chat. With its ability to support self-service of routine EHR-integrated requests, it can schedule appointments and respond to a wide variety of inquiries.

TeleVox has demonstrated significant market traction, being awarded an AI chatbot agreement with Premier, Inc. in 2024 and showcasing innovations at major healthcare conferences, including HLTH 2024 and HIMSS 2025.

The platform represents a comprehensive best AI chatbot for healthcare solution that addresses both virtual assistant capabilities and human agent integration.

Reasons to Choose TeleVox

• HIPAA-compliant omnichannel platform: Handles patient queries through phone, text, and online chat with full healthcare compliance and EHR integration capabilities.
• AI-driven SMART Agent: Compiles a dynamic knowledge base using AI to decipher patient inquiries and respond with relevant information from authorized healthcare resources.
• Agent Chat integration: Agent Chat seamlessly connects patients with a live agent through a secure chat link. It is ideal for referral outreach, managing appointments, and assisting patients with bill pay. It can also be used for general patient questions, filling care gaps, and much more.
• Comprehensive self-service capabilities: Supports appointment management, bill pay integration, prescription refills, and procedure eligibility with zero IT setup required.

2. Kore.ai

Kore.ai provides enterprise-grade AI chatbots for healthcare platforms that integrate with your existing systems to address provider, payer, and life sciences use cases. The company raised $150 million in funding in 2024, demonstrating strong market confidence in its conversational AI solutions.

Their healthcare solution, Kore HealthAssist, brings conversational AI for voice and text interactions to healthcare providers, enabling communication with patients, providers, and insurance agents.

Importantly, the platform offers a comprehensive AI stack with pre-built solutions and an agent platform featuring no-code development tools. Your organization can deploy custom chatbots without extensive technical expertise, making it accessible for various healthcare settings.

Reasons to Choose Kore.ai

• No developers are required to start: Simple drag-and-drop functions and templates enable you to create intelligent chatbots without any need for coding expertise.
• You get built-in security and compliance. You keep your patients’ data safe and comply with all healthcare standards.
• Everything connects seamlessly: Your patients get the same consistent experience across all channels without frustrating handoffs or repeating information.
• Covers both patient and staff needs: Automate everything from appointment scheduling and insurance verification to internal workflow tasks, reducing workload across your entire organization.

3. Ada Health

Ada Health operates as both a consumer health app and an enterprise AI chatbot for healthcare platforms. The platform was created by doctors and offers AI-powered symptom assessment and health guidance tools.

Known for its accurate symptom checker and health assessment tools, Ada Health provides users with sound insights to make informed medical decisions. The platform integrates medical expertise with AI to deliver personalized health checks and care suggestions.

Reasons to Choose Ada Health

• Actual medical knowledge behind each interaction: Ada asks proper questions and gives evaluations based on a database that healthcare professionals developed and tested, so guidance is medically valid.
• Keeps patients engaged beyond initial consultation: Create medication reminders, appointment reminders, and follow-up questionnaires to oversee continued care instead of merely diagnosing issues.
• Works with multilingual patient populations: Support for many different languages enables you to work with diverse communities without compromising on medical accuracy for any interactions.
• Clinicians trust and utilize it: Based on strong clinical principles and tested in real-life medical environments, it becomes a tool that enhances clinical judgment instead of replacing it.

4. Hyro

Hyro specializes in AI chatbot automation for healthcare with a platform designed specifically for communication workflows.

Patients can find doctors easily, with multiple attributes, in their own natural language, 24/7. They can also automatically refill prescriptions and get immediate access to pharmaceutical information. The platform handles core healthcare administrative tasks through conversational AI.

Hyro’s solution integrates with existing healthcare systems and electronic health records to provide seamless patient experiences. The system includes an AI-driven inbox that automates document processing to reduce administrative tasks.

Reasons to Choose Hyro

• Provides instant savings: You save millions in almost no time by streamlining workflows, while patients receive quicker and more natural reactions to their needs.
• Does much more than a simple chatbot: Schedules automatically by verifying eligibility and availability, takes intake information, and seamlessly integrates with your current scheduling systems without any manual intervention.
• Makes informed decisions on patient requests: Determines whether to resolve something automatically, send a self-service link as a text, or route to the appropriate department so patients aren’t sent around unnecessarily.
• Cuts down your staff hours: Your staff gets back nearly 4,000 hours every month via automated routine calls, allowing them to focus on high-value interactions.

5. Florence

Florence serves as both an AI-driven consumer health app and an enterprise solution. It offers medication reminders, symptom tracking, and general health information. The platform provides evidence-based healthcare delivery through automated clinical conversations via text messaging.

The platform is notable for being WHO’s AI-powered digital health worker. It was originally designed to combat COVID-19 disinformation, but now can give advice on mental health, tips to de-stress, guidance on how to eat healthily and be more active, and how to quit tobacco and e-cigarettes.

Reasons to Choose Florence

• Extensive medical monitoring: Monitor health indicators, track prescriptions, and understand treatment plans through an intuitive interface.
• Supported by WHO: Designed as WHO’s official evidence-based digital health worker with AI power and global health knowledge.
• Medication management excellence: Mitigates risk of missed doses and reduces medication-related complications through user-friendly features.
• Multilingual Support: Available in English with Arabic, French, Spanish, Chinese, Hindi, and Russian language support coming soon.
• Evidence-based clinical conversations: You get a care service that supports routine healthcare delivery with 20 peer-reviewed studies.

6. Sensely

Sensely is a conversational AI platform centered on “Molly,” a virtual medical assistant that enables patients to verify symptoms, monitor chronic diseases, and get reliable health information. The platform stands out for combining voice, text, images, and video to provide more natural and interactive experiences.

Reasons to Choose Sensely

• Communicates like a real person: “Molly” can talk, text, and use images or video to understand patient symptoms, making interactions feel natural and comprehensive.
• Actually listens and responds: Advanced voice recognition lets patients speak normally about their symptoms or schedule appointments without typing or navigating complicated menus.
• Plugs right into your existing systems: Connects seamlessly with electronic health records to manage chronic conditions and personalize care based on patient history.

7. Kyruus Health

Kyruus Health connects 425,000 providers across more than 1,000 hospitals and 500 medical groups, and more than 150 million health plan members across 100 health plan brands.

Kyruus’ Guide, a conversational AI search experience, utilizes natural language processing and generative AI to create a seamless and intuitive experience for members seeking care.

The solution leverages Kyruus Health’s expertise in supporting over 1 billion searches for care and helps members select a provider that best fits their medical and personal preferences.

Reasons to Choose Kyruus Health

• Conversational AI search experience: Guide leverages natural language processing and generative AI to assist members in identifying providers that align with their medical and personal needs.
• Huge provider network: Connects 425,000 providers in 1,000+ hospitals and 500+ medical groups, providing broad access to care options.
• Record-breaking growth: Delivered record-breaking growth in 2024, with proven success supporting over 1 billion care searches.
• Enhanced member engagement: Payer customers experience up to 114% increases in member interactions with enhanced provider profiles and scheduling capabilities.

8. Youper

Youper is an AI mental health assistant that helps people better understand and manage their emotions. It’s trusted by over 3 million users, and has been featured in outlets like Forbes and Bloomberg.

The platform’s built to support emotional well-being through thoughtful, interactive conversations. Each session involves questions that take into account your responses. The app actually listens and adapts questions to help you build emotional awareness.

Reasons to Choose Youper

• Most users see real improvement: Over 80% people using it report better mental health management, showing it works for the majority of patients who try it.
• Gets patients thinking deeper: Uses smart follow-up questions that help people reflect on their emotions and build self-awareness over time.
• Built on proven therapeutic methods: Uses evidence-based approaches with safety as the top priority, designed to support professional therapy rather than trying to replace it.

9. Mosaicx

Mosaicx offers an advanced conversational AI platform that specializes in voice recognition and digital messaging to help patients find information quickly and resolve issues without an agent. It focuses on improving patient experience outside the clinic through IVAs for healthcare solutions.

Mosaicx has demonstrated a significant impact in healthcare, notably helping Vibrant Emotional Health improve access to urgent mental health care through the 988 Lifeline. Together, they’ve successfully routed 10 million contacts, including calls, texts, chats, and video phone interactions, showcasing their capability as the best AI chatbot for customer service in healthcare solutions.

Reasons to Choose Mosaicx

• Manages high volumes of patients through all channels: Handles thousands of daily interactions via phone calls, text messages, chats, and mobile apps, so patients can contact you any way they like.
• Patients can talk naturally: Advanced voice recognition allows individuals to speak naturally without having to wait for a human being or juggle confusing phone menus.
• Three decades of reliability: 30+ years of enterprise experience means you’re getting proven technology that healthcare organizations can depend on day after day.
• Reaches patients before escalation: Facilitates proactive outreach and personalized interactions that keep patients connected with their care outside of your clinic.

AI Healthcare Chatbot Use Cases

Healthcare chatbots serve multiple functions within healthcare organizations. They handle routine patient interactions while maintaining compliance with healthcare regulations. Here are the top use cases:

• Patients don’t have to call the office anymore just to make or change an appointment. They can schedule, cancel, or reschedule at their leisure through the wonders of automated scheduling.
• Once a patient leaves the treatment center to go home, the follow-up does not end. The system contacts them with brief messages, asks for progress in recovery, and notifies the care team in case something is amiss.
• Regular reminders for doses, refills, and possible drug interactions are automatically forwarded to encourage patients to remain steady and prevent problems.
• When someone reports symptoms, the system steps in with smart, focused questions to assess what’s going on. Hence, patients are guided to the most appropriate care level by your chatbots.

Benefits of AI Chatbots in Patient Engagement

AI-driven healthcare chatbots are always available, offering patients assistance whenever they need it. Their constant support helps create deeper connections between patients and providers. Hence, their benefits extend beyond basic convenience:

• Support doesn’t stop when the office closes. With 24/7 access, patients can get the information they need anytime, helping ease worries and keeping their care on track.
• Health education is also made more personal. Rather than generic guidance, patients are given content specific to their individual conditions, treatments, and risk factors, making it easier to follow and implement.
• Simple questions no longer result in long waits. Instant answers pop up, and more complex ones are automatically forwarded to the appropriate team member with all the context required to jump in right away.
• Following a care plan gets a boost, too. Routine check-ins and gentle nudges help patients stay consistent with their treatment, reducing setbacks and improving outcomes.
• For healthcare teams, it’s a smart way to stretch resources. Routine tasks are handled efficiently without extra staff, so patients still feel supported without driving up costs.

How To Choose the Right AI Chatbot Partner for Healthcare

Certain evaluations must be made before investing in an AI chatbot for your healthcare organization. The right enterprise-grade solution should demonstrate proven experience and offer measurable results.

• Privacy isn’t a choice in healthcare. That’s why top-performing AI chatbots include full encryption, secure access controls, and written HIPAA compliance built into every interaction and integration.
• They must connect directly to your EHR, pulling and updating patient data in real-time without the need for any manual entries.
• Daily operations should get a boost as well. Automation ensures that all your clinical workflows are handled by the system without any human intervention.
• Your AI system should support thousands of daily patient interactions while providing detailed reporting on response times and patient satisfaction to track ROI and improvement areas.

Reasons Why Regular AI Chatbots Aren’t Feasible for Large-Scale Health Systems

Most healthcare organizations start by considering popular AI tools like ChatGPT for patient communication. This approach creates problems quickly.

These general-purpose chatbots weren’t built for healthcare environments. They miss critical security requirements and can’t handle the complexity of medical operations.

Enterprise-grade AI-driven healthcare chatbots, like those from TeleVox, solve these issues by focusing specifically on healthcare needs from the ground up.

• They don’t meet healthcare data security requirements: ChatGPT and similar tools send patient conversations to external servers, where other companies control the data. Healthcare organizations need systems that keep all patient information within secure, auditable environments that meet HIPAA standards without compromising on functionality.
• They don’t integrate with EHRs: Healthcare operations require chatbots that pull information directly from EHR systems. Regular chatbots can’t do this.
• They fail stress tests: Regular chatbots can’t handle the load of a busy healthcare system. We’re talking thousands of daily patient calls, messages, and interactions. That too, across multiple departments.

Effective Patient Engagement With TeleVox’s AI-Powered Agents

Response times are often the real bottleneck in patient communication. TeleVox’s conversational AI eliminates the wait (and resulting frustration) by instantly understanding your patient’s intent, responding with precision, and escalating complex issues where they need to go without your staff lifting a finger.

SMART Agent, our AI-powered concierge, takes it a step further. From scheduling changes to post-visit follow-ups, it handles everyday conversations with accuracy and context, freeing your team to focus on care.

This isn’t just fast. It’s built for the scale, security, and systems that enterprise healthcare demands.

Ready to see it in action? Book a demo and experience the difference for yourself.